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This blog is set up for our CL1202 module - Microbiology B
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Poxviridae ( History of smallpox and its eradication)
Tuesday, January 27, 2009/ 2:02 AM
Unique featues
Poxviridae is the largest family of viruses, which can be seen under a light microscope. It has linear dsDNA covalently cross linked at ends. Important characteristic of poxvirus is that it is remains stable for hours in air.
Poxvirus can be split into 2 major groups and they are
Bioterrorism
(watch the video on the how pox virus is used as bioterrorism)
Poxviridae is the largest family of viruses, which can be seen under a light microscope. It has linear dsDNA covalently cross linked at ends. Important characteristic of poxvirus is that it is remains stable for hours in air.
Poxvirus can be split into 2 major groups and they are
- Chordopoxviriniae(poxvirus of vertebrates) and
- Entomopoxvirinae( poxvirus of insects)
Clinical features
- human is the only host
- causes respiratory secretions
- causes skin lesions
- 12-7 days of incubation
- there are nine types of poxvirus that causes the disease
- variola (infects human) and vacinnia (infects cow)
- show inflenza like sympotoms
- form pustules which scars the skin
- if not treated it causes blindness or even
(watch the video on the features of small pox)
Vaccination
- Edward jenner was the first person came out the first vaccination for small pox
- used cow pox(vaccinia which is used as vector) from milkmaids
- to vaccinate james phipps
- and cured him
Eradication
- no reservoir for vaccinia or variola except man
- causes acute infection where the patients dies or obtains life long immunity
- is also an efficient immunogen.
Lab diagnosis, epidemology, control
- it was eradicated in 1980
- it was found to be infectious during symptoms and not during incubation.
- best defence against small pox was vaccination
- last outbreak in happened in yugoslavia in 1972
- after the outbreak the infectious materials was incinerated
- now the vaccination have stopped
Bioterrorism
(watch the video on the how pox virus is used as bioterrorism)
Labels: selvi